Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 492-98-8, name is 1H,1’H-2,2′-Biimidazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H6N4
Synthetic example 8:1 ,1 ‘-bis(4-(1 OH-phenothiazin-10-yl)phenyl)-1 H,1 ‘H^’-biimidazole8A mixture of 1H,1’H-2,2′-biimidazole (480 mg, 3.6 mmol), 10-(4-bromophenyl)-10H- phenothiazine (3.80 g, 10.8 mmol) and Cs2C03 (5.85 g, 18.0 mmol) in DMF (60 mL) was degassed (N2 bubbling, 15 min). CU2O (210 mg, 1.5 mmol) was added and the mixture was heated (140 C, 72h). The mixture was allowed to cool to room temperature and filtered through Celite washing with CH2CI2. The combined filtrate and washings were concentrated. The mixture was diluted with CH2CI2 and H2O and the organic phase was separated. The aqueous phase was re-extracted (CH2CI2) and the combined organics were washed (saturated aqueous NaCI), dried (MgS04), filtered and concentrated to give a solid residue. The residue was purified by flash chromatography (EtOAc/CH2CI2/MeOH 40:60:0 then 38:60:2 then 35:60:5) to give 1 ,1′-bis(4-(10H-phenothiazin-10-yl)phenyl)-1H,1’H-2,2,-biimidazole (1.12 g, 46%) as a colourless solid. A portion of this material was further purified firstly, by recrystallisation (CH2CI2/toluene/petrol) and then by distillation (sublimation apparatus 260 C, 10″6 mBar): m.p. 227 – 232 C (DSC); 1H NMR (CDCI3, 400 MHz) delta 6.36 – 6.42 (m, 4H), 6.86 – 6.97 (m, 12H), 7.08 – 7.16 (m, 8H), 7.20 (br s, 2H), 7.35 (br s, 2H); 13C NMR (CDCI3, 100 MHz) delta 118.4, 123.6, 123.8, 125.4, 126.8, 127.4, 128.4, 130.5, 135.2, 141.5, 143.3; HRMS (El) m/z 679.1710 C^Hzr^ [M – Hf requires 679.1733.
According to the analysis of related databases, 492-98-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; MACDONALD, James Matthew; BOWN, Mark; UENO, Kazunori; WEBER, Karl Peter; O’CONNELL, Jenny Lee; HIRAI, Tadahiko; WO2012/51666; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem