Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H10F3N3
Methyl 3-((tert-butoxycarbonyl)amino)-4-methylbenzoate (Intermediate A, 39.8 g, 0.15 mol, 1.5 eq.),3-(4-Methyl-1-1H-imidazole)-5-trifluoromethylaniline (starting material SM2, 24.1 g, 0.1 mol, 1.0 eq.) and N,N-dimethylformamide (250 ML).The reaction mixture was cooled to -10 to 0 C, and potassium t-butoxide (56.1 g, 0.5 mol, 5.0 eq.) was added to the reaction mixture and stirred for 2 to 3 hours.The reaction was monitored by high performance liquid chromatography, and water (100 mL) was added to the reaction mixture.A 3N aqueous hydrochloric acid solution was added to the system to adjust the pH to 7-8. filter,The filter cake is dried to give 2-methyl-5-((3-(4-methyl-1-1H-imidazole)-5-(trifluoromethylphenyl)carbamoylphenyl)carbamic acid tert-butyl 45.1 g of ester (intermediate B),A crude white to yellow solid with a purity of 94.8% and a molar yield of 95%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-11-1, its application will become more common.
Reference:
Patent; Shanghai Fu Xingxing Tai Pharmaceutical Technology Co., Ltd.; Liu Xuejun; Chen Xiaodong; Hao Lu; Wu Feng; (23 pag.)CN109666023; (2019); A;,
Imidazole – Wikipedia,
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