Adding a certain compound to certain chemical reactions, such as: 15469-97-3, name is 1-Trityl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15469-97-3, Application In Synthesis of 1-Trityl-1H-imidazole
Take the imidazole salt (395 mg, 0.5 mmol), 1-trityl imidazole (550 mg, 1.8 mmol), anhydrous potassium carbonate (61 mg, 4.4 mmol), palladium dichloride (78.5 mg, 44 mmol) After vacuuming with nitrogen, anhydrous THF (6 mL) was added and the mixture was refluxed for 20 h. After the reaction solution was cooled to room temperature, it was diluted with dichloromethane, and the crude product was purified by column chromatography.The pale yellow product was obtained 278 mg, yield 53percent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Trityl-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Patent; Tianjin Normal University; Liu Guiyan; Han Fangwai; Liu Chengxin; Xu Ying; (9 pag.)CN108690086; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem