Synthetic Route of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dimethyl (2-(6-fluoro-2-(2-hydroxypropan-2-yl)benzofuran-5-yl)-2-oxoethyl)phosphate (0207-60) (400 mg, 1.47 mmol, 3.3 eq),2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (180 mg, 0.44 mmol, 1.0 equiv) andCesium carbonate (958 mg, 2.94 mmol, 2.0 eq.)Added to 40 ml of isopropanol,Stir the reaction overnight at room temperature,Concentrate under reduced pressure, add ethyl acetate and water, separate, dry over anhydrous sodium sulfate, and concentrate under reduced pressure to obtain 1-(6-fluoro-2-(2-hydroxypropan-2-yl)benzofuran-) as a yellow solid. 5-base)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-en-1-one (540 mg, crude)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Trityl-4-imidazolyl)benzaldehyde, its application will become more common.
Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
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