Reference of 15788-16-6, The chemical industry reduces the impact on the environment during synthesis 15788-16-6, name is 1H-Benzo[d]imidazole-5-carboxylic acid, I believe this compound will play a more active role in future production and life.
Example 1 N2-((lH-Benzo[d]imidazol-5-yl)methyl)-N’-(5-cyclopropyl-lH-pyrazol-3-yl)pyrimidine-2,4- diamine (I- 13) step 1 : Thionyl chloride (10 mL) was added dropwise to a solution of lH-benzo[d]imidazole-5-carboxylic acid (4.8 g, 30 mmol) in MeOH (150 mL) cooled to 0 C. The reaction mixture was heated at reflux for 18 h, and then solvent (about 2/3) was concentrated under reduced pressure. After cooling, a yellow solid was precipitated from the solution and was filtered to afford 4 g (90%) of methyl lH-benzo[d]imidazole- 5-carboxylate (20): MS (ESI) m/z = 111 [M+l]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Benzo[d]imidazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim; WO2013/26914; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem