Electric Literature of 2302-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2302-25-2, name is 4-Bromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
b) 4-Bromo-1-phenyl-1H-imidazoleA mixture of 4-bromo-lH-imidazole (3000 mg, 20.4 mmol, Eq: 1.00), iodobenzene (3.75 g, 2.05 ml, 18.4 mmol, Eq: 0.9), copper (I) iodide (194 mg, 1.02 mmol, Eq: 0.05), 8- hydroxyquinoline (148 mg, 1.02 mmol, Eq: 0.05) and cesium carbonate (8.85 g, 27.1 mmol, Eq: 1.33) was dissolved in DMF (45.0 ml) and water (4.5 ml). The mixture was stirred for 2.5 days at 130 C. The residue was diluted with ethyl acetate and washed with water, ammonium chloride sol. sat. and sodiumhydrogen carbonate sat. The organic layer was separated, dried over magnesium sulfate, filtrated and evaporated. The crude material was applied on silica gel and purified by flash chromatography over a 70 g silica gel column using heptane / ethyl acetate 10-30 % as eluent affording 4-Bromo-l -phenyl- lH-imidazole (2.345 g, 51.5%) as off-white solid. MS: m/z= 222.98 (M+)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; WO2015/78836; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem