Synthetic Route of 570-22-9,Some common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, molecular formula is C5H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
All reagents and solvents used to obtain (1) and (2) were of p.a.quality, and used without any previous purification process. A suspensionin continuous stirring of H3IDC (0.156 g, 1.00 mmol), 2,2-bipyridine (0.078 g, 0.50 mmol) and 70 lL of dipropylamine(DPA) in 10 mL of acetonitrile (MeCN), was mixed with a solutionof Cu(NO3)23H2O (0.121 g, 0.50 mmol) in 10 mL of H2O/MeCN 1:1. The deep blue slurry solution was filtered and the supernatantwas kept at room temperature for 1 day providing blue needle-likecrystals, which can be isolated by filtration. As the crystals turnedopaque under air suggesting a loss of crystallinity, for X-ray experimentsthe crystals were picked out and immediately glued toavoid any solvent loss. MW: 565.9 g/mol. Yield of 82%, based oncopper salt.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole-4,5-dicarboxylic acid, its application will become more common.
Reference:
Article; Cruz, Carlos; Spodine, Evgenia; Venegas-Yazigi, Diego; Paredes-Garcia, Veronica; Polyhedron; vol. 136; (2017); p. 117 – 124;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem