Related Products of 2735-62-8, These common heterocyclic compound, 2735-62-8, name is 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of nitrile (33a, b, 36a-f, i) (1.0mmol) in pyridine (2.5mL) was added 2-mercaptoacetic acid or 37a-c (1.0mmol), and the mixture was stirred at reflux for 8h. After addition of H2O (10mL), the mixture was extracted with EtOAc (3×10mL) and the combined organic layers were washed with brine (30mL) and dried (MgSO4). Evaporation of the solvent followed by chromatography (hexane-EtOAc, 1:1) of the residue gave thiazole (5, 6, 10, 14, 16-20 and 24).
The synthetic route of 2735-62-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sogame, Shinya; Suenaga, Yoshihito; Atobe, Masakazu; Kawanishi, Masashi; Tanaka, Eiichi; Miyoshi, Shiro; European Journal of Medicinal Chemistry; vol. 71; (2014); p. 250 – 258;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem