Electric Literature of 3012-80-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3012-80-4, name is 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 4 3-Acetyl-6-chloro-4-phenylquinolin-2(1H)-one (100 mg, 0.31 mmol) was added to a solution of NaOH (18 mg, 0.44 mmol) in EtOH (20 mL) and H2O (1 mL). The mixture was stirred at room temperature for 30 mins. Then 1-methyl-1H-benzo[d]imidazole-2-carbaldehyde (60 mg, 0.37 mmol) was added and the mixture was stirred at 35° C. overnight. The mixture was concentrated to dryness and the residue was diluted with EA (10 mL). The mixture was washed with water (10 mL), brine (10 mL) and dried over anhydrous Na2SO4. The mixture was concentrated to give a crude solid, which was purified by prep-HPLC to give 6-chloro-3-[3-(1-methyl-1H-benzoimidazol-2-yl)-acryloyl]-4-phenyl-1H-quinolin-2-one (50 mg, yield: 37percent) as a yellow solid. 1HNMR (400 MHz, DMSO-d6): delta=12.41 (brs, 1H), 7.69-7.02 (m, 13H), 7.01 (d, J=3.2 Hz, 1H), 3.88 (s, 3H). MS: m/z 440.1 (M+H+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Sanford-Burnham Medical Research Institute; The Royal Institution for the Advancement of Learning / McGill University; The Government of the United States of America as Represented by the Secretary of the Department of; RONAI, Ze’ev; PINKERTON, Anthony B.; FENG, Yongmei; TOPISIROVIC, Ivan; BROWN, Kevin; HASSIG, Christian A.; (155 pag.)US2018/44324; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem