Reference of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of imidazole 5 (20.4 g, 0.3 mol) in 95% sulfuric acid(60 mL), was heated up to 70 C and 60 mL of 65% nitric acid wasadded dropwise thereto. The temperature of the resulting mixturewas then elevated to 100 C and refluxed for 5 h. The reaction solutionwaspoured onto 100 g crushed ice and neutralized with 25%ammonia solution. Filtration, washing and drying were furtherperformed to give 6 as a white solid (23 g, 67% yield); mp:311-312 C (lit. mp 310-311 C) [40].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.
Reference:
Article; Shirvani, Pouria; Fassihi, Afshin; Saghaie, Lotfollah; Van Belle, Siska; Debyser, Zeger; Christ, Frauke; Journal of Molecular Structure; vol. 1202; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem