Reference of 137049-00-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows.
Vi) l-Methyl-lH-imidazole-4-sulfonic acid (4-chloro-benzyl)-(2-ethyl-4,4-dimeihyl- l-oxo-l,2,3,4-tetrahydro-isoquinolin-7-yl)-amideTo a stirred solution of 7-(4-chloro-benzylamino)-2-ethyl-4,4-dimethyl-3,4-dihydro-2H-isoquinolin-l-one (17 mg, 0.05 mmol) and pyridine (9 mul, 0.11 mmol) in anhydrous acetonitrile (1 ml) was added 1 -methyl- lH-imidazole-4-sulfonyl chloride (20 mg, 0.11 mmol) and the reaction heated to 150C in a microwave for 0.5 hrs. The solvent was evaporated in vacuo and the crude residue purified by preparative tic (5% methanol in dichloromethane) to afford the title compound as a colourless solid (5 mg, 21%). HPLC retention time 4.42 min. Mass spectrum (ES+) m/z 487 (M+H).
The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-imidazole-4-sulfonyl chloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; XENTION LIMITED; HAMLYN, Richard, John; MADGE, David; MULLA, Mushtaq; WO2010/139953; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem