Synthetic Route of 4856-97-7,Some common heterocyclic compound, 4856-97-7, name is (1H-Benzoimidazol-2-yl)methanol, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: One of compounds 4a?4f (5 mmol) was dissolved in THF (25 mL) and DCC (1.24 g, 6 mmol), and DMAP (0.12 g, 1 mmol) was slowly added and the mixture was stirred for 30 min. Compounds 2a?2c (5 mmol) was added and the mixture was stirred for 7?9 h. The by-product, N,N’-dicyclohexylurea, was removed by filtration. The filtrate was concentrated in vacuum to give a solid which was dissolved in CH2Cl2 and the product 5a?5n was filtered off. (1H-Benzoimidazol-2-yl)methyl 1H-indole-3-carboxylate (5a). Light green solid, yield 90 percent, mp 190?192°C. 1H NMR spectrum, delta, ppm: 5.49 s (2H, CH2), 7.18 m (4H, ArH), 7.50 t (J = 5.0 Hz, 2H, ArH), 7.61 d (J = 7.5 Hz, 1H, ArH), 8.01 d (J = 7.2 Hz, 1H, ArH), 8.21 s (1H, CH?N), 12.02 s (1H, NH), 12.60 s (1H, NH). HRMS (EI): m/z: calculated 291.1008 for C17H13N3O2[M]+, found 291.1005.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (1H-Benzoimidazol-2-yl)methanol, its application will become more common.
Reference:
Letter; Zhang; Xu; Wang; Kang; Russian Journal of General Chemistry; vol. 87; 12; (2017); p. 3006 – 3016;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem