Adding a certain compound to certain chemical reactions, such as: 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20485-43-2, Safety of 1-Methyl-1H-imidazole-2-carboxylic acid
To a solution of i-methyl-I H-imidazole-2-carboxylic acid (500 mg, 3.57 mmol, commercially available from e.g. Sigma-AIdrich), Lambda/-[3-(dimethylamino)propyl]-N’- ethylcarbodiimide (554 mg, 3.57 mmol) and 1-H-1 ,2,3-benzotriazol-1-ol (54.6 mg, 0.357 mmol) in dichloromethane (20 ml) pre-stirred for 30 mins under argon at room temp was added solid t-butyl carbazate (722 mg, 5.35 mmol). The reaction mixture was stirred at RT for 18 h. The reaction mixture was partitioned between dichloromethane (~ 50 ml) and saturated sodium bicarbonate solution (~ 50 ml). The aqueous phase was extracted with dichloromethane (2 x 25 ml) and the combined organic extracts washed with saturated sodium bicarbonate solution (~ 25 ml), dried over magnesium sulphate and evaporated in vacuo to give the crude product as a yellow oil. This was purified via Biotage (1 :1 Hex/EtOAc; 40+M Biotage column) to afford the required product as a white solid in 143.8 mg.LCMS: 2 minute run in MeOH. [M-Boc+H]+ = 140.93; RT = 0.57-0.59 min
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem