Application of 4499-07-4,Some common heterocyclic compound, 4499-07-4, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine dihydrochloride, molecular formula is C9H13Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The ligand L1 was synthesized by a condensation reaction between 2-aminoethyl-1H-benzimidazole dihydrochloride (1.170g, 5mmol), previously neutralized with K2CO3 (0.828g, 6mmol), and pyridine-2-carbaldehyde (0.535g, 5mmol) in 25mL of methanol. The reaction mixture was stirred at room temperature for approximately 2h. The resulting brown solution was removed on a rotatory evaporator and the light brown product was then filtered and recrystallized from EtOH for two times. Yield: 1.06g (85%). m.p.: 155-156C. IR (KBr pellet, cm-1): 1635(nuC=N), 1437(nuC=C-C=N). 1H NMR (500MHz, DMSO-d6, ppm) delta: 3.22-3.25 (t, 2H, -CH2-), 4.05-4.08 (t, 2H, -CH2-), 7.42-8.97 (m, 8H, Ar-H), 8.98 (s, 1H, -CH=N-), 12.61 (br s, 1H, NH). UV-Vis (methanol, lambdamax, nm): 204, 248, 276, 281. Anal. Calc. for C15H14N4: C, 71.98; H, 5.64; N, 22.38. Found: C, 71.86; H, 5.57; N, 22.29%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Benzo[d]imidazol-2-yl)ethanamine dihydrochloride, its application will become more common.
Reference:
Article; Zhao, Hai-Yan; Yang, Fu-Li; Li, Na; Wang, Xiao-Jing; Journal of Molecular Structure; vol. 1148; (2017); p. 62 – 72;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem