Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54624-57-6, name is 2-Bromobenzimidazole, A new synthetic method of this compound is introduced below., name: 2-Bromobenzimidazole
(1) in 250mL three-necked flask,Purged with nitrogen,0.02mol raw material 2-bromo-1H-benzimidazole was added,0.03mol iodobenzene,0.04 mol sodium hydride, 0.004 mol copper iodideAnd 0.01 mol of o-phenanthroline were dissolved in 100 ml of 1,3-dimethyl-2-imidazolidinone,The reaction was stirred for 20-30h,After the reaction was completed, water was added and the mixture was extracted with methylene chloride. The organic layer was dried over anhydrous sodium sulfate and rinsed with a mixture of petroleum ether and ethyl acetate. The volume ratio of petroleum ether to ethyl acetate in the eluent was 1 : 100, purified by column chromatography to give Intermediate M1;HPLC purity 99.5%, yield 75.8%.
The synthetic route of 54624-57-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Zhang Zhaochao; Tang Dandan; Li Chong; (40 pag.)CN106946853; (2017); A;,
Imidazole – Wikipedia,
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