Adding a certain compound to certain chemical reactions, such as: 13275-42-8, name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13275-42-8, Quality Control of 2-(2-Bromophenyl)-1H-benzo[d]imidazole
Take a quartz reaction tube, add a magnetic stirrer thereto, and then add 0.3 mmol of 2-(2-bromophenyl)benzimidazole (CAS No. 13275-42-8).0.9 mmol of lithium t-butoxide (t-BuOLi), 20 mmol% of cuprous iodide (CuI), N,N-dimethylformamide (DMF) 1 mL, acetonitrile (CH3CN) 1 mL, and finally 0.6 mmol of benzyl amine. Then add a three-way air guide head with a balloon above the quartz reaction tube.First, the reaction liquid is frozen with liquid nitrogen, and then the quartz reaction tube is evacuated by an oil pump, and then the balloon is filled with nitrogen;Under the stirring of magnetic stirrer, the reaction was carried out under nitrogen conditions and ultraviolet light of 254 nm for 12 hours.Then, it was reacted under air conditions and ultraviolet light of 254 nm for 24 hours, and the reaction was completed.The final product was detected by TLC, and finally the final product, 6-phenylbenzimidazole [1,2-c]quinazoline, was isolated by column chromatography, yield 90%.
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Reference:
Patent; Henan University; Xu Hao; Liu Yawei; Xu Jing; Wang Yanpeng; Ren Yanrong; Liu Baoying; Zhang Wenkai; Xu Yuanqing; Fang Xiaomin; Ding Tao; (10 pag.)CN108610345; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem