In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25676-75-9 as follows. Computed Properties of C4H5BrN2
Step 2: preparation of benzyl 5-(1-methylimidazol-4-yl)isoindoline-2-carboxylate (compound 45b) To a solution of benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline-2-carboxylate (compound 45a, 76 mg, 0.20 mmol) in THF/H2O (4.5 mL, v/v = 8/1) was added 4-bromo-1-methyl-1H-imidazole (32 mg, 0.20 mmol), and K3PO4 (85 mg, 0.40 mmol). The solution was bubbled with N2 for 5 mins, then cataCXium A Pd G2 (134 mg, 0.20 mmol) was added. The mixture was heated at 75 C overnight, then cooled to rt and concentrated to give a crude product which was purified by column chromatography to give compound 45b (43 mg) as an oil. MS: calc’d 334 (MH+), measured 334 (MH+).
According to the analysis of related databases, 25676-75-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. Hoffmann-La Roche AG; The designation of the inventor has not yet been filed; (99 pag.)EP3623369; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem