Adding a certain compound to certain chemical reactions, such as: 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71759-87-0, Formula: C4H5IN2
Preparation 78tert-butyl (3S,4R)-4-{[3-carbamoyl-5-( 1-methyl-i H-imidazol-4-yl) pyridin-2-ylloxy}-3-fluoropiperidine- 1 -carboxylate To a solution of tert-butyl (3S,4R)-4-{[3-carbamoyl-5-(4,4, 5, 5-tetramethyl- 1, 3,2-dioxaborolan-2- yl) pyridin-2-yl]oxy}-3-fluoropiperidine- 1 -carboxylate (Preparation 99, 900 mg, 1.94 mmol) and 4- iodo-i-methyl-1H-imidazole (403 mg, 1.94 mmol) in DMF (15 mL) was added a solution of potassium carbonate (534 mg, 3.87 mmol) in water (2 mL) and the mixture degassed with argon for 15 minutes. i,i-bis(diphenylphosphino)ferrocene palladium (II) dichloride (79 mg, 0.097mmol) was added and the reaction heated to 100C for 16 hours. The reaction was cooled, diluted with EtOAc, washed with water, brine, dried over sodium sulphate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 3-5% MeOH in DCM to afford the title compound (400 mg, 49%).1H NMR (400 MHz, DMSO-d6): O ppm 1.41 (5, 9H), 1.81-1.86 (m, 1H), 1.96-1.99 (m, 1H), 2.95-3.30 (m, 2H), 3.68 (5, 3H), 3.98-4.03 (m, 1H), 4.10-4.21 (m, 1H), 5.00 (d, 1H), 5.42-5.50 (m, 1H),7.53 ( br 5, 1 H), 7.67 (5, 1 H), 7.69 (5, 1 H), 7.82 (br 5, 1 H), 8.54 (d, 1 H), 8.63 (d, 1 H). MS mlz 420 [M+H]
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Reference:
Patent; PFIZER LIMITED; SKERRATT, Sarah Elizabeth; BAGAL, Sharanjeet Kaur; SWAIN, Nigel Alan; OMOTO, Kiyoyuki; ANDREWS, Mark David; WO2015/92610; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem