Related Products of 5465-29-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5465-29-2 name is 2-Propylbenzimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of 22 (65 mg, 0.18 mmol) and 2-propylbenzo[d]imidazole (32 mg, 0.20 mmol) in DMF (1.5 mL) was added potassiumcarbonate (125 mg, 0.908 mmol), and the solution was stirredfor 4 h at 60 C. After the consumption of the starting material, thereaction mixture was poured into water and extracted twice with ethylacetate. The combined organic layers were washed with brine, driedover sodium sulfate, and filtered. The organic layer was concentrated togive the residue. The obtained residue was then purified by flashcolumn chromatography on silica gel (100:0 to 50:50 hexane/ethylacetate) to give 25 (63 mg, 79%) as an amorphous. 1H NMR (300 MHz,CDCl3): delta 0.98 (t, J=7.4 Hz, 3H), 1.71-1.93 (m, 2H), 2.23 (s, 3H),2.74-2.91 (m, 2H), 4.73 (d, J=12.4 Hz, 1H), 5.23-5.38 (m, 3H),6.72-6.85 (m, 2H), 6.90-7.18 (m, 7H), 7.39-7.47 (m, 1H). LC/MS (ESI,[M+H]+, m/z) 438.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Propylbenzimidazole, and friends who are interested can also refer to it.
Reference:
Article; Yamamoto, Keisuke; Tamura, Tomohiro; Nakamura, Rina; Hosoe, Shintaro; Matsubara, Masahiro; Nagata, Keiko; Kodaira, Hiroshi; Uemori, Takeshi; Takahashi, Yuichi; Suzuki, Michihiko; Saito, Jun-ichi; Ueno, Kimihisa; Shuto, Satoshi; Bioorganic and Medicinal Chemistry; vol. 27; 22; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem