Application of 124750-92-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 124750-92-1, its application will become more common.

Some common heterocyclic compound, 124750-92-1, name is Losartan carboxylic acid, molecular formula is C22H21ClN6O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Losartan carboxylic acid

Step B: 2-butyl-4-chloro-l- { [2 ‘ – (2-trityl-2H-tetrazol-5- yl) biphenyl-4-yl] methyl } -IH-imidazole-5-carboxylic acid To a solution of E3174 (234.58 g, 0.54 mol) in DCM (4500 mL) was added triethylamine (85 mL, 0.59 mol) followed by a solution of trityl chloride (159 g, 0.56 mol) in DCM (800 mL) and the reaction mixture was stirred at rt overnight. The reaction mixture was washed with water, dried (MgSO4), filtered, and concentrated in vacuo. Chromatography over silica eluting with 20-80% acetone/heptane afforded the title compound as an orange solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 124750-92-1, its application will become more common.

Reference:
Patent; NICOX S.A.; MERCK & CO. INC.; WO2009/106470; (2009); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem