Related Products of 53981-69-4,Some common heterocyclic compound, 53981-69-4, name is 1-(1H-Imidazol-2-yl)ethanone, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 1-(3-bromopropyl)-4-chlorobenzene (1.5 g) and 2-acetylimidazole (0.87 g) in DMF (15 mL) was added potassium carbonate (3.6 g). The mixture was stirred for 1.5 hours at 70 C and allowed to cool to room temperature. The reaction was quenched with water and extracted with EtOAc. The organic layer was washed with brine three times and concentrated in vacuo onto ISOLUTE HM-N. The residue was purified with OH-type silica gel column chromatography (1-20 % MeOH in CHCI3) to give the title compound (Intermediate- 1, 1.6 g, 94 % yield) as light yellow oil. -NMR, MS and LCMS retention time data of Intermediate- 1 are shown in Table 1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(1H-Imidazol-2-yl)ethanone, its application will become more common.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; TAKASHIMA, Hajime; SASAKI, Toru; TANAKA, Nozomi; OTAKE, Norikazu; TSURUTA, Risa; YAMADA, Yousuke; MATSUDA, Yohei; OGATA, Yuya; (346 pag.)WO2018/216822; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem