Application of 144689-93-0, These common heterocyclic compound, 144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1: To the reaction portion were added 85 g of ethyl 4- (1-hydroxy-1-methylethyl) -2-propyl-imidazole-5-carboxylate (Formula 2), 4- [2- (trityltetrazol- ) Phenyl] benzyl bromide (Formula 3), 32.4 g of potassium tertiary phosphate (K3PO4) and 600 mL of N, N-dimethylacetamide were added and the mixture was stirred at a temperature of 60 to 65 DEG C for 6 hours. Then, the mixture was stirred for 1 hour while gradually adjusting the temperature to 25 to 30 . 400 mL of ethyl acetate was added to the reaction solution, and 1 L of purified water was slowly added dropwise over 30 minutes while stirring, and crystals were precipitated. The resulting crystals were stirred at 25 to 30 DEG C for 2 hours, filtered and washed with 1 L of purified water and then dried at 55 to 60 DEG C for 12 hours to obtain ethyl 4- (1-hydroxy-1-methylethyl) 226 g (yield 89.3%, purity 99.95%) of 1- {4- [2- (trityltetrazol-5-yl) phenyl] phenyl} -methylimidazole-5-carboxylate .
The synthetic route of 144689-93-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DONGBANG FTL CO., LTD; Song, Tae Hong; Jung, Hun Suk; Jang, Do Yeon; Moon, Chung Sun; Jung, Hee Jung; (18 pag.)KR101526249; (2015); B1;,
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