Reference of 2034-22-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2034-22-2, name is 2,4,5-Tribromoimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure for the synthesis of AB1 To a stirred solution of 2,4,5-tribromoimidazole (1.0 g, 3.28 mmol) in tetrahydrofuran (15.0 mL) was added NaH (60% dispersion in paraffin, 0.20 g, 4.92 mmol) under ice-bath. After 10 min, chloromethyl methyleter (0.30 mL, 3.94 mmol) was added slowly. The reaction mixture was allowed to room temperature and further stirred for 1.5 hours. The reaction mixture was quenched with water (20 mL) and extracted with EtOAc (20 mL x 2). The organic layer was dried over anhydrous MgS04 and concentrated in vacuo to give AB1.
The synthetic route of 2,4,5-Tribromoimidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INSTITUT PASTEUR KOREA; TERRAMARK MARKENCREATION GMBH; KIM, Jaeseung; KANG, Sunhee; KANG, Juhee; LEE, Sumi; SEO, Jeong Jea; SEO, Mooyoung; (156 pag.)WO2015/193506; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem