Synthetic Route of 22884-10-2, These common heterocyclic compound, 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 50 mL flask was added 4-chloro-orthozilidine 1c (1 mmol), alpha-bromo-tert-butyl ketone (1.2 mmol), and potassium carbonate (1.5 mmol), and reacted at 45 C, The reaction solvent was chloroform (20 mL). After reacting for 2 hours, diphenylmethylphosphine (1.5 mmol) was further added, and the reaction was carried out at 30 C. After the reaction was continued for 3 hours, the solvent chloroform was removed under reduced pressure. The residue was transferred to a solution of triphenylphosphine (2.5 mmol) and iodine (2.5 mmol) in chloroform (15 mL). After reacting for 2 hours, after completion of the reaction, the solvent chloroform was removed under reduced pressure. Residue column chromatography gave 0.223 g of the title compound 2c. The yield was 71%.
Statistics shows that 2-(1H-Imidazol-1-yl)acetic acid is playing an increasingly important role. we look forward to future research findings about 22884-10-2.
Reference:
Patent; China Three Gorges University; Wang Long; Yang Qingqing; Li Yongshuang; Li Dejiang; (8 pag.)CN109265448; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem