Related Products of 39021-62-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.
A 20 mL vial equipped with a stir bar was charged with the recovered amine 62 and product mixture (0.330 mmol, 1 equiv.), 43.3 mg of l-methyl-lH-imidazole-4-carbaldehyde (0.390 mmol, 1.2 equiv.), 0.019 mL of CH3COOH (0.330 mmol, 1 equiv.) and 3.4 mL of CH2CI2 and stirred at rt for 3 h. Then 111 mg of NaBH(OAc)3 (0.520 mmol, 1.6 equiv.) was added. After stirring at rt for 12 h, the reaction mixture was quenched by addition of sat. NaHCCb solution and sat. Na2CCb sol., and the product was extracted with CH2CI2 (3x) and dried over Na2S04. The crude product was purified on silica gel column (12 g) using 0-30 % MeOH in EA as eluent affording 116 mg (43%) of N-((S)-3-((R)-3-(((4-(l,3-dioxoisoindolin-2-yl)butyl)((S)-5,6,7,8-tetrahydroquinolin-8- yl)amino)methyl)-4-((1 -methyl- lH-imidazol-5-yl)methyl)piperazin- 1 -yl)- 1 -phenylpropyl)-4,4- difluorocyclohexane-l -carboxamide 78 as a yellowish foam.
The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-imidazole-5-carbaldehyde. I believe this compound will play a more active role in future production and life.
Reference:
Patent; EMORY UNIVERSITY; LIOTTA, Dennis C.; JECS, Edgars; ALTAS TAHIROVIC, Yesim; WILSON, Lawrence; PELLY, Stephen Christopher; (102 pag.)WO2019/183133; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem