Adding a certain compound to certain chemical reactions, such as: 3304-70-9, name is Dimethyl 4,5-imidazoledicarboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3304-70-9, COA of Formula: C7H8N2O4
1H-Imidazole-4,5-dicarboxylic acid dimethyl ester (1.5 g, 8.15 mmol, 1 equiv. ) was dissolved in MeOH (10 mL) and benzyl bromide (1.16 mL, 9.77 mmol, 1.1 equiv.) before sodium hydride (360 mg, 1.1 equiv., 60% dispersion) and sodium iodide (200 mg) was added. The reaction was stirred for 16 hours before being quenched with saturated NH4Cl (30 mL) and extracted with ethyl acetate (2 x 30 mL) and the organic layer washed several times with water (4 x 30 mL), brine solution (50 mL). It was dried over Na2S04, filtered and concentrated in vacuo. 1-Benzyl-1H- imidazole-4,5-dicarboxylic acid dimethyl ester 254 (2.01 g, 90 %, 7.33 mmol). ¹H NMR (300 MHz) CDC13 No. 7.58 (s, 1 H), 7.33 – 7.42 (m, 3 H), 7.14 – 7.18 (m, 2 H), 5.41 (s, 2 H), 3.92 (s, 3 H), 3.84 (s, 3 H). MS: 275.1 (M+1)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Dimethyl 4,5-imidazoledicarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; GILEAD SCIENCES, INC.; CAI, Zhenhong, R.; CHEN, Xiaowu; FARDIS, Maria; JABRI, Salman, Y.; JIN, Haolun; KIM, Choung, U.; METOBO, Sanuel, E.; MISH, Michael, R.; PASTOR, Richard, M.; WO2005/117904; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem