Electric Literature of 57090-88-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57090-88-7, name is 1H-Imidazole-4-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of 2-bromo-l-(2,4-difluorophenyl)ethanone (63.1 g, 269 mmol) and 4-cyano- IH- imidazole (25.0 g, 269 mmol, 1.0 eq) in acetonitrile (200 mL) was added NN-diisopropylethylamine (93.81 mL, 69.4 g, 537 mmol, 2.0 eq) and zinc(II) chloride (3.66 g, 26.86 mmol, 0.10 eq) at 30C. The reaction mixture was stirred at 70 C for 12 hours. The reaction mixture was filtered and concentrated in vacuum. The residue was purified by column chromatography on silica gel (petroleum ether: ethyl acetate =1 :1) to give a mixture of desired 3-[2-(2,4-difluorophenyl)-2-oxo-ethyl]imidazole-4-carbonitrile and its regioisomeric by-product 1- [2-(2,4-difluorophenyl)-2-oxo-ethyl]imidazole-4-carbonitrile as an approximately 40:60 mixture (total : 30.0 g, combined yield: 45%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; COQUERON, Pierre-Yves; BERNIER, David; MILLER, Ricarda; GENIX, Pierre; NAUD, Sebastien; WITTROCK, Sven; BRUNET, Stephane; KENNEL, Philippe; MEISSNER, Ruth; WACHENDORFF-NEUMANN, Ulrike; (124 pag.)WO2018/60074; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem