Reference of 3543-73-5, The chemical industry reduces the impact on the environment during synthesis 3543-73-5, name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, I believe this compound will play a more active role in future production and life.
Method B: To a 500 mL three-neck glass flask equipped with a heating mantle, thermocouple, condenser, nitrogen inlet/outlet, and overhead stirrer was charged 4-(5-amino-l- methyl-lH-benimidazol-2-yl)-butyric acid ethyl ester (6.4g, 1.0 eq.), chloroacetic acid (42.5 g), and tetrahydrofuran (THF, 13 mL). The resulting mixture was stirred for 1.5 hours in a water bath at room temperature. Borane-THF (150 mL) was added over 20 minutes. Once the charge was complete, the reaction mixture was heated to 55-58 C and stirred for 1.5 hours. In-process analysis by HPLC showed 94A% of the desired product. The reaction was cooled to room temperature and telescoped to the next step of hydrolysis to generate bendamustine.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CEPHALON, INC.; BAKALE, Roger, P.; BROWN, Peter, D.; CHEN, Jian; DRAGER, Anthony, S.; LABELL, Rachel, Y.; MCKEAN, Robert, E.; PATEL, Piyush, R.; ROEMMELE, Renee, C.; WO2014/75035; (2014); A1;,
Imidazole – Wikipedia,
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