In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2849-93-6 as follows. COA of Formula: C8H6N2O2
A mixture of compound 70 (0.7 g, 2.1 mmol, 1 eq), 1H-benzimidazole-2-carboxylic acid (358 mg, 2.2 mmol, 1.1 eq), HATU (881mg, 2.3 mmol, 1.1 eq), TEA (426 mg, 4.2 mmol, 586 tL, 2 eq) in 10 mL of DMF was degassed and purged with N2 3 times, and then the mixture was stirred at 15 C for 12 hours under N2 atmosphere. The reaction mixture was partitioned between 20 mL of water and 20 mL of EtOAc. The organic phase was separated, washed three times with 45 mL of water and 15 mL of brine, dried over Na2SO4, filtered and concentrated under reduced pressure to give a residuewhich was purified by flash silica gel chromatography (ISCO; 20 g SepaFlash Silica Flash Column, Eluent of 020% ethyl acetate/petroleum ether gradient 60 mL/min) to give 0.37 g of compound 71(745 imol, 35% yield, 95.9% purity) as a white solid.
According to the analysis of related databases, 2849-93-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem