312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 312-73-2
The -1H- benzimidazol-2-trifluoromethyl-2 (1.35g, 10mmol) was added to a round bottom flask containing 15mL of acetone were added ene (propargyl) propyl bromide dissolved with stirring (0.87mL, 10mmol) and K2CO3(2.07g, 15mmol), was heated under reflux, TCL is detected, after completion of the reaction, cooling was cooled, solid was removed by filtration, the solid was washed with methylene chloride, the solution was concentrated acetone solution was mixed with dichloromethane, washed with H2O wash (15mL × 3), the organic phase was dried over anhydrous MgSO4Dried, filtered and concentrated to give crude product.To give 1-propargyl-2-trifluoromethyl–1H- benzoimidazol (3) 2.06g, yield 91.96%.
The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Wang, Yuguang; Zhu, Bingchun; Dong, Huichan; (11 pag.)CN104530008; (2016); B;,
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