Application of 3543-73-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3543-73-5 name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 1 :Preparation of lH-benzimidazol-l-methyI-5-N,N-di(2-hydroxyethyl)-2-butanoic acid ethyl esterlH-Benzimidazol-l-methyl-5-amino-2-butanoic acid (50 gm), water (285 ml) and acetic acid (80 ml) were added at room temperature. The solution was then cooled to 0 to 5C under stirring and ethylene oxide gas was passed in the reaction till the reaction mixture weight increases to 60 gm. The reaction mass was maintained for 1 hour at 0 to 5C and then temperature allowed to room temperature. The reaction mass was maintained for 30 hours at room temperature and then added water (2000 ml) and dichloromethane (2000 ml). To the reaction mass was added sodium bicarbonate (230 gm) and then the layers were separated. The aqueous layer was extracted with dichloromethane. The organic layers were combined and the solvent was distilled off under vacuum to obtain a residual solid. To the residual solid was added hexane (400 ml) and stirred for 30 minutes at room temperature. The solid obtained was collected by filtration, washed with cyclohexane and then dried at 35 to 40C for 2 hours 30 minutes to obtain 63 gm of lH-benzimidazol-l-methyl-5-N,N-di(2-hydroxyethyl)-2-butanoic acid ethyl ester.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, and friends who are interested can also refer to it.
Reference:
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; VAMSI KRISHNA, Bandi; WO2012/176214; (2012); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem