Application of 15108-18-6,Some common heterocyclic compound, 15108-18-6, name is 2-Hydrazinyl-1H-benzo[d]imidazole, molecular formula is C7H8N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-hydrazino-1 H-benzimidazole (5.0 g, 33.7 mmol) in ethanol (30 ml) is added sequentially triethylamine (5 ml, 33.7 mmol) and N-cyanoformimidic acid ethyl ester (3.3 g, 33.7 mmol) with cooling. After stirring for 2 hours at 0C the resulting precipitate is filtered with suction and dried to give 3-, amino-2-(1 H-benzimidazol-2-yl)-1, 2, 4-triazole. 1H- NMR (400 MHz, d6-DMSO) : 13.0 (s, 1 H) ; 7.77 (s, 1 H) ; 7.70 (m, 2H); 7.50 (m, 2H); 7.20 (s, 2H).
The synthetic route of 15108-18-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASILEA PHARMACEUTICA AG; WO2005/77939; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem