Related Products of 28890-99-5, These common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate compound 1: (E)- 1 ,3-dibromo-2-(4- methoxystyryl)benzene is synthesized starting from the formation of phosphonium salt with 1,3-dibromo-2-(bromom- ethyl)benzene and triphenylphosphine, followed by Wittig olefination with 4-methoxybenzaldehyde. 1 then undergoes hydrogenation to afford 1 ,3-dibromo-2-(4-methoxyphen- ethyl)benzene, whereby the methoxy sub stituent is deprotected to give phenol derivative intermediate compound 2. Intermediate compound 2 is treated with standard palladium catalyzed reaction conditions to form diaryl ether 3 from intramolecular C-O cross-coupling using known methods (Journal of the American Chemical Society 2011, 133, 9282-92 85, which is incorporated by reference herein in its entirety). 3, together with 1 ,3-dibromobenzene and dichlorodiphenylsilane, undergoes lithiation with n-butyllithium to afford intermediate compound 4. Inventive host compound 5 is then synthesized by a cross-coupling reaction between4 and 5H-benzo[d]benzo[4,5]imidazo[1 ,2-a]imidazole under standard l3uchwald-Hartwig amination reaction conditions.
Statistics shows that 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole is playing an increasingly important role. we look forward to future research findings about 28890-99-5.
Reference:
Patent; Universal Display Corporation; Wolohan, Peter; Drennan, Diana; Fitzgerald, George; (171 pag.)US2018/315942; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem