Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, A new synthetic method of this compound is introduced below., HPLC of Formula: C29H22N2O
2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (250 mg, 0.6 mmol, 1.0 equiv),Compound (dimethyl 2-(isoquinolin-6-yl)-2-oxoethyl)phosphate (0803-127) (400 mg, 1.4 mmol, 2.3 eq.)And cesium carbonate (391 mg, 1.2 mmol, 2.0 equiv)Mixed in isopropyl alcohol (30 ml),The reaction was stirred at room temperature overnight.After the reaction is completed, quench with water, extraction with dichloromethane, anhydrous sulfur in the organic phaseThe sodium sulfate was dried and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=100/1-50/1) to give a product.1-(isoquinolin-6-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-en-1-one (300 mg, Rate: 87%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem