Adding a certain compound to certain chemical reactions, such as: 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-70-8, name: 1-(1H-Benzo[d]imidazol-2-yl)ethanone
Synthesis of target compound Y-0: 2-acetylbenzimidazole (1 mmol) at 0 CTo a solution of ethanol (10 mL) was added 60% aqueous potassium hydroxide solution (3 mL) and benzaldehyde (1 mmol),Stir at room temperature until the reaction is complete. TLC monitors the progress of the reaction.After the reaction is complete, add crushed ice and dilute hydrochloric acid solution, adjust the pH to form a precipitate,The crude extract was dried by filtration and purified by column chromatography to obtain the target compound Y-0.(Synthesis method see literature: European Journal of Medicinal Chemistry 143 (2018) 66-84) Yield: 62.6%;
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Reference:
Patent; Lanzhou University; Liu Yingqian; Wang Renxuan; Li Juncai; Yang Chengjie; Chen Yongjia; Peng Jingwen; Yin Xiaodan; Yan Yinfang; (10 pag.)CN110839636; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem