Synthetic Route of 124312-73-8, These common heterocyclic compound, 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Chloro-6-N-(7i-propyl)amino-[1,3,5]triazin-2-yl)-N,0-dimethyl- hydroxylamine (CD) (1 g, 4.5 mmol), (l-methyl-1H-imidazol-2-yl)methanamine (600 mg, 5.4 mmol) and KaC03 (1.24 g, 9 mmol) in EtOH (50 mL) were heated at 100 C for 16 h. The reaction mixture was filtered, and the volatiles were removed under reduced pressure. The residue was dissolved in EtOAc (100 mL), washed with water (30 mL) and then with a brine solution (30 mL), and lastly dried over Na2S0 . The solvent was removed under reduced pressure. The crude product was purified by flash column chromatography (DCM MeOH=20/l to 8/1) to yield 4-N-(l-N- methylimidazol^-y^-methylamino-e-N-in-pro y amino-tl.S^Itriazin^-yl^NjO- dimethyl-hydroxylamine (CVII, 650 mg, 47%).
Statistics shows that (1-Methyl-1H-imidazol-2-yl)methanamine is playing an increasingly important role. we look forward to future research findings about 124312-73-8.
Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott, L.; WOODWARD, Richard; PENG, Sean; WO2012/74999; (2012); A1;,
Imidazole – Wikipedia,
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