Some common heterocyclic compound, 714273-83-3, name is 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde, molecular formula is C8H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 714273-83-3
To a solution of compound 5 (50 g329 mmol) in EtOH (200 mL), NaBD4 (41 g, 979 mmol) was added portion wise under nitrogen. The mixture was stirred for 5 h at -20. The precipitate was removed by filtration. To the filtrate, 2 mol/L aqueous hydrochloric acid (250 ml) was added, and then filtrated. The filtrate was evaporated in vacuo, and then dissolving in water, the pH of the solution was adjusted to 8-9 using saturated potassium carbonate. The crude product was gain by filtration to get 44g compound 6 with a yield at 85%, and was used for next step without further purification. 1H NMR (500 MHz, CDCl3) delta 7.72 (s, 1H), 1.48 (s, 9H). MS (ESI): m/z = 157.22 [M + H] +
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 714273-83-3, its application will become more common.
Reference:
Article; Ding, Zhongpeng; Cheng, Hejuan; Wang, Shixiao; Hou, Yingwei; Zhao, Jianchun; Guan, Huashi; Li, Wenbao; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1416 – 1419;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem