Related Products of 123470-47-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123470-47-3, name is 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: An oven-dried Schlenk tube equipped with a Teflon valve was charged with a magnetic stir bar, CuI (0.075 mmol), 1,10-phenanthroline (0.15 mmol), 1,8-diiodonaphthalene 1a (0.5 mmol), 1H-benzo[d]imidazole-2-thiols or 2-thiouracils b (0.5 mmol) and base (1.0 mmol). The tube was placed under vacuum for twenty minutes and backfilled with N2, then DMF (2.0 mL) was added via syringe. The reaction mixture was stirred at 100 oC for 24 h. The reaction was monitored by TLC. When b consumed completely, the reaction was stopped and cooled to room temperature, EtOAc (40 mL) was added and the mixture was washed with brine (20 mL × 3). The organic phase was dried over Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel using petrol/EtOAc (3:1, v:v) as eluent to give c.
The chemical industry reduces the impact on the environment during synthesis 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione. I believe this compound will play a more active role in future production and life.
Reference:
Article; Cui, Jichun; Zhang, Tongxin; Wang, Jianhua; Liu, Dezhi; Wang, Jiaqian; Liu, Jie; Shen, Guodong; Synthetic Communications; vol. 49; 8; (2019); p. 1076 – 1082;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem