These common heterocyclic compound, 124750-92-1, name is Losartan carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 124750-92-1
Step B: To the dichloromethane solution of step A product was added triethylamine followed by the addition of triphenylmethyl chloride in methylene chloride and the resulting reaction mixture was stirred at room temperature. The reaction mixture was triturated with water, dried over magnesium sulfate, filtered, concentrated in vacuo, loaded on a silica gel column and eluted with 20-80% acetone / n-hexane to give2-Butyl-4-chloro-1 – {[2 ‘- (2-trityl-2H-tetrazolyl-5) biphenyl-4-] methyl} -1H-imidazole- carboxylic acid.
The synthetic route of Losartan carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Yongtai Technology Co., Ltd.; Lin, Jiaohua; He, Renbao; (22 pag.)CN104447899; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem