Application of 39021-62-0, These common heterocyclic compound, 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under N2 at -78 100 mL 3-neck round bottom flask at nBuLi (hexane of 2.5 M, 0.52 mL, 1.3 mmol) to dry THF (10 mL) of 6-bromo-2,4-dichloro-3 – phenyl quinoline (353 mg, 1 mmol, intermediate 1: step c) was added dropwise to a solution of. Continuous stirring for 30 minutes, was added a solution of dry THF (10 mL) of 1-methyl -1H- imidazole-5-carbaldehyde (110 mg, 1 mmol) at -78 . The cooling bath was removed and was gradually The mixture was warmed to RT, stirred for 2 hours. The mixture was then quenched by the addition of H2O (10 mL), extracted with CH2Cl2 (2 × 50 mL). Dry the combined organic phases with Na2SO4 and concentrated to dryness, prep-TLC: Purification of (CH3OH / CH2Cl2 1 evolves to 5) to give the title compound as a white solid.
Statistics shows that 1-Methyl-1H-imidazole-5-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 39021-62-0.
Reference:
Patent; Janssen Pharmaceuticals N.V; Leonardo, Christi.A.; Barvei, Kent; Edward, James P.; Gloita, Kevin D.; Kummer, David .A.; Maharoof, Umar; Nishimura, Rachael; Urbanski, Mode; Venkatesan, Hariharan; Wang, Ai Hua; Olin, Ronald L.; Woods, Craig; Fourier, Anne; Shu, Jih; Cumings, Maxwell D.; (86 pag.)KR2016/68948; (2016); A;,
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