Synthetic Route of 68282-47-3, The chemical industry reduces the impact on the environment during synthesis 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.
COMPOUND 12.1. 11: NqN-DIETHYL-4- {7-METHOXY-2-[(2-PHENYL-1H- IMIDAZOL-5-YL) METHYL1-L24-TETRAHYDROISOOUINOLIN-1- YUBENZAMIDE; INTERMEDIATE 4.2. 2 (24 mg, 0.07 mmol) and 2-phenylimidazole-4 (5)- carbaldehyde (48 mg, 0.28 mmol) were dissolved in DCE (2.0 mL) and NMP (0.2 mL). After stirring for 10 min at room temperature, sodium triacetoxyborohydride (59 mg, 0.28 mmol) was added and the mixture was stirred for 18 h at room temperature. DCM and 1 M sodium hydroxide solution were added and the mixture was passed through a Whatman IPS silicon-treated filter paper. The organic phase was evaporated and the crude product was purified by flash chromatography to yield the product (13 mg, 0.026 mmol, 37%). lH NMR (500 MHz, CDC13) : 8 1. 10, 1.24 (2 brs, 6H), 2.73, 2. 82, 3. 00, 3.17 (4 m, 4H), 3.25, 3.54 (2 brs, 4H), 3.62 (s, 3H), 3.68 (m, 2H), 4.89 (s, 1H), 6.21 (s, 1H), 6.73 (d, J 8. 5 Hz, 1H), 6.90 (s, 1H), 7.05 (d, J 8. 5 Hz, 1H), 7.27-7. 38 (m, 7H), 7.90 (m, 2H). 13C NMR (125 MHz, CDC13): 6 12.8, 14.2, 26.4, 39.5, 43.4, 46.6, 49.1, 55.2, 66.9, 113.2, 113.8, 125.9, 126.5, 129.0, 129.7, 129.9, 157.9, 171.1. (+) LRESIMS m/z 495 [M+H] +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Phenyl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem