Application of 54624-57-6,Some common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To the corresponding benzimidazole or pyrazole 16?20 (4.5 or 6.6 equiv), dissolved under N2 atmosphere in anhyd MeCN, NaH (60percent dispersion in mineral oil, 4.5 or 6.6 equiv) was added and the mixture was stirred for 30 min at r.t. Then, the bromomethyl-substituted benzene derivative 15, 21 or 23 (1 equiv) was added and the reaction mixture was stirred for up to 5 d at r.t. under N2 atmosphere. The reaction was quenched with H2O (10 mL) and extracted with CHCl3 (3 × 10 mL). The organic layers were combined, dried over MgSO4 and filtered, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography using CHCl3?MeOH or CHCl3?MeOH?hexane as the eluent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromobenzimidazole, its application will become more common.
Reference:
Article; Koch, Niklas; Mazik, Monika; Synthesis; vol. 45; 24; (2013); p. 3341 – 3348;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem