Related Products of 41716-18-1, The chemical industry reduces the impact on the environment during synthesis 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.
Into a 50 mL round bottom flask equipped with a magnetic stir bar was placed 1-methyl-1H-imidazole-4-carboxylic acid (121 mg, 0.93 mmol), DMF (10 mL), ACN (20 mL), DIPEA(0.321 mL, 1.864 mmol), and HATU (378 mg, 0.99 mmol). This mixture was allowed tostirS mm at room temperature, afterwards 11(400 mg, 0.621 mmol) was added. The flaskwas sealed and allowed to stir at room temperature for 24 hours. The reaction mixture was reduced in volume, then poured into water (400 mL), and partitioned with ethyl acetate (3 x 100 mL). The organic layers were combined, dried over sodium sulfate, the solids were removed by filtration, and the solvent of the filtrate was removed underreduced pressure. The crude was purified by silica gel column chromatography using a n-heptane to ethyl acetate gradient. The best fractions were pooled and the solvent was removed under reduced pressure to afford 12. LC-MS ES mlz = 638.5; Rt: 2.34 mm, method B.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; GUILLEMONT, Jerome Emile Georges; COOYMANS, Ludwig Paul; EMBRECHTS, Werner Constant Johan; BUYCK, Christophe Francis Robert Nestor; BALEMANS, Wendy Mia Albert; RABOISSON, Pierre Jean-Marie Bernard; (34 pag.)WO2017/89518; (2017); A1;,
Imidazole – Wikipedia,
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