Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1848-84-6, name is 2-Ethyl-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Ethyl-1H-benzo[d]imidazole
A mixture of (5-chloro-7-morpholin-4-ylthiazolo[5,4-J]pyrimidin-2-yl)-[4-(l- hydroxy-l-methylethyl)piperidin-l-yl]methanone (250 mg, 0.59 mmol), 2- ethylbenzimidazole (90 mg, 0.62 mmol), tris(dibenzylideneacetone)dipalladium (15 mg, 2.5 molpercent), XPhos (25 mg, 10 molpercent) and Cs2CO3 (270 mg, 0.83 mmol) in DMF (6 mL) was purged with argon then heated at 150 0C for 30 min in a microwave reactor. The reaction mixture was purified by column chromatography (Si-PCC, MeOH:DCM, 1-5percent) followed by recrystallisation from Et2O and EtOAc affording 771 (109 mg, 35percent). LCMS (method I): Rx 3.96 min [M+H]+ 536.3. 1H NMR (CDCl3, 400 MHz): delta 8.06-8.05 (1 H, m), 7.76-7.75 (1 H, m), 7.32-7.28 (2 H, m), 5.22 (1 H, d, J = 13.34 Hz), 4.84 (1 H, d, J = 13.16 Hz), 4.41 (4 H, brd s), 3.89 (4 H, t, J = 4.74 Hz), 3.37 (2 H, q, J = 7.46 Hz), 3.17-3.15 (1 H, m), 2.84-2.82 (1 H, m), 1.94 (2 H, t, J = 13.72 Hz), 1.72-1.62 (1 H, m), 1.49-1.40 (5 H, m), 1.23 (6 H, d, J = 7.01 Hz)
The synthetic route of 1848-84-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; CASTANEDO, Georgette; CHAN, Bryan; GOLDSTEIN, David Michael; KONDRU, Rama K.; LUCAS, Matthew C.; PALMER, Wylie Solang; PRICE, Stephen; SAFINA, Brian; SAVY, Pascal Pierre Alexandre; SEWARD, Eileen Mary; SUTHERLIN, Daniel P.; SWEENEY, Zachary Kevin; WO2010/138589; (2010); A1;,
Imidazole – Wikipedia,
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