Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4856-97-7, name is (1H-Benzoimidazol-2-yl)methanol, A new synthetic method of this compound is introduced below., Application In Synthesis of (1H-Benzoimidazol-2-yl)methanol
To an ice-bath cooled solution of 18 (0.50 g, 3.38 mmol) in anhydrous DMF (7 ml) was added sodium hydride (NaH; 0.08 g, 3.38 mmol). After stirring at 0 °C for approx. 15 min (or after no more visible emergence of hydrogen), the mixture was allowed to warm up to room temperature and kept stirred for an additional 45 min. The mixture was then re-cooled to 0 °C, and benzyl chloride (0.39 ml, 3.38 mmol) was slowly added. The mixture was first stirred 1 h at 0C and then overnight at room temperature. The mixture was then quenched with cold water and crushed ice and extracted with DCM (2x). The combined organic layer was washed with brine, dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography (100percent DCM to DCM/MeOH; 97:3 stepwise gradient) to give the title compound as a yellow sticky solid (0.62 g). Yield: 77percent; mp: 157-159 °C; IR (Nujol): 3142, 2920, 2852, 1606, 1416, 1463, 1344, 1214, 1043, 856, 734; 1H NMR (300 MHz, CDCl3): delta 4.88 (s, 2H), 5.46 (s, 2H), 7.00-7.16 (m, 2H), 7.16-7.41 (m, 6H), 7.71 (d, 1H); MS (EI+) m/z: 238 [M+].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Darwish, Khaled M.; Salama, Ismail; Mostafa, Samia; Gomaa, Mohamed S.; Helal, Mohamed A.; European Journal of Medicinal Chemistry; vol. 109; (2016); p. 157 – 172;,
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