Synthetic Route of 827-43-0, These common heterocyclic compound, 827-43-0, name is 4-Methyl-2-phenyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of bicyclic olefin 2a (0.2083 mmol, 1.75 equiv),2-phenylimidazole (0.1191 mmol, 1.0 equiv), [RhCl2Cp*]2(0.0029 mmol, 2.5 mol%), and Cu(OAc)2·H2O (0.1338mmol, 1.5 equiv) were weighed in a Schlenk tube anddegassed for 10 min. Anhydrous MeCN (2 mL) was added,and the reaction mixture was purged with argon and allowedto stir at 80 C for 12 h. The solvent was evaporated invacuo, and the residue was purified with columnchromatography (silica gel, 100-200 mesh) using anEtOAc-hexane mixture. Mono- and biscyclopentenylfunctionalizedaza heteroaromatics were obtained in 48%and 39% yields, respectively.
Statistics shows that 4-Methyl-2-phenyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 827-43-0.
Reference:
Article; Prakash, Praveen; Aparna; Jijy; Santhini; Varughese, Sunil; Radhakrishnan; Synlett; vol. 25; 2; (2014); p. 275 – 279;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem