In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1403474-70-3 as follows. Application In Synthesis of Ethyl 2-ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
Example 2 Preparation of the product 2-Ethoxy-3- [2 ‘- (5-oxo-4,5-dihydro- [1,2,4] oxadiazol-3-yl) 4-ylmethyl] -3H-benzimidazole-4-carboxylate 55.1 g,0.4 MN NaOH into the reaction bottle,75 C stirring reaction to the raw material reaction is completed. The reaction solution was cooled to room temperature. The filtrate was added with 820ml of absolute ethanol, filtered and kept at 20 C. The pH was adjusted to 1 with 2M HC1 solution. A large amount of solid was precipitated, stirred for 1 hour, filtered and washed with water. 50.6 g,HPL (^ i ^ S 98.6%
According to the analysis of related databases, 1403474-70-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hunan Xianjin Xiangjiang Pharmaceutical co., LTD; YUAN, XIUJU; YAO, LIANGYUAN; ZONG, AIJUN; DENG, MENGRU; (12 pag.)CN103664921; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem