Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1849-02-1, name is 2-Chloro-1-methyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1849-02-1
EXAMPLE 39; CYCLOHEXYL-ETHYL- {2- [4- (1-METHYL-1 H-BENZOIMIDAZOL-2-YLOXY)-PHENYL]-ETHYL}- amine; A mixture of 4- [2- (cyclohexyl-ethyl-amino)-ethyl]-phenol (247 mg, 1.0 MMOL), N- methyl benzimidazole (EXAMPLE 8 ; 200 mg, 1.2 MMOL), and CS2CO3 (652 mg, 2.0 MMOL) in DMF (3 mL) was stirred at 100 C for 16 h. The reaction mixture was cooled and filtered through diatomaceous earth, which was then washed with ethyl acetate (30 mL). The combined filtrates were washed with H20 (3 x 10 mL) then brine (10 mL), dried (NA2SO4), filtered, and concentrated under reduced pressure. The crude material was purified on SI02 (10 g; 0-100% 10% [2 M NH3 in CH30H] in CH2CI2/CH2C12) to provide 105 mg (28% yield) of a brown oil. MS (ESI) : mass calculated for C24H3INSO, 377.53 ; M/Z FOUND, 378.4 [M+H] +. H NMR (400 MHz, CDC13) : 7.52 (d, J =7. 2, 1 H), 7.63-7. 58 (m, 1 H), 7.33-7. 18 (m, 7H), 3.75 (s, 3H), 2.81-2. 70, m, 4H), 2.68 (q, J = 7.1, 2H), 2.60- 2.50 (m, 1H), 1. 90-1. 80 (m, 4H), 1.67 (d, J : = 12.3, 1 H), 1.35-1. 18 (m, 4H), 1.15-1. 05 (m, 1H), 1.12 (t, J=7. 1, 3H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1849-02-1.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/12296; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem