Adding a certain compound to certain chemical reactions, such as: 1072-62-4, name is 2-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-62-4, SDS of cas: 1072-62-4
The 400mg4-amino-6-chloro-pyrimidine, 317 mg (1.1equiv) 2-ethyl imidazole, 1.2g (1.2equiv) adding cesium carbonate flask, 10mLN, N ‘-dimethyl formamide as a solvent, the temperature is increased to 120 C, reaction 18h. Adding proper amount of water, extraction with ethyl acetate, saturated salt water washing, drying by anhydrous sodium sulfate, filter, evaporate solvents under reduced pressure, the residue is purified by silica gel column chromatography separation, methanol/dichloromethane = 1/30 elution, to get the yellow solid 105 mg, yield 18%.
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Reference:
Patent; East China University of Technology; Mao, Fei; Wang, Huan; Li, Xiaokang; Zhang, Haiyan; Lu, Zhengyu; Li, Jian; (43 pag.)CN105418592; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem