Reference of 20970-50-7, A common heterocyclic compound, 20970-50-7, name is 1-(1-Methyl-1H-imidazol-5-yl)ethanone, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[2516] Dissolve 365 (0.24 g, 0.49 mmol) in THF (2.5 ml). Cool under N2 to -78 C., add (1) (BuLi, 2.5M, 0.2 ml) and stir the resulting dark brown solution for 15 minutes. Dissolved 883 (0.116 g) from Step C in 0.5 mL of THF and add to reaction and stir at -78 C. for 3 hours. Add reaction mixture to brine and extract with ethyl acetate(2×). Dry with MgSO4, filter and evaporate to obtain a yellow solid. Purified crude (0.29 g) by Prep Plate Chromatography to afford 0.0.15 g, 42% yield of the desired product (795.1).
The synthetic route of 20970-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Schering Corporation; US2004/122018; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem